在评估癌症发病率时,参考组选择的重要性
Alexandra K Mueller1,2, Brandon Vaeth1,2, Andrew C Todd3
1Bureau of Health Services, World Trade Center Health Program, Fire Department of the City of New York, Brooklyn, NY, USA.
Scientific reports
|January 2, 2025
概括
参考人口的选择显著影响了世界贸易中心 (WTC) 响应者的癌症发病率和趋势. 不同组的结果各不相同,这影响了随着时间的推移对癌症风险的评估.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 世界贸易中心 (WTC) 暴露与响应者癌症发病率升高有关.
- 观察到的癌症发病率 (IRR) 显示时间变化.
- 参考人群选择对这些趋势的影响尚未完全理解.
研究的目的:
- 分析不同基准人群如何影响WTC暴露响应者的相对癌症发病率和时间趋势.
- 用纽约市 (NYC),纽约州 (NYS) 和美国人口参考来比较癌症发病率.
- 研究参考组选择对确定癌症发病率的时间变化点的影响.
主要方法:
- 利用了从2002-2015年到2015年的WTC联合救援/恢复队列 (65,691名参与者) 的数据.
- 使用波桑回归来估计发病率比率 (IRR),控制年龄,种族/种族和日历年份.
- 使用三个不同的参考人群估计的IRR和变化点:纽约市,纽约州和美国一般人口.
主要成果:
- 根据癌症部位和参考人群,IRR有显著的差异.
- 与所有参考组相比,前列腺癌和甲状腺癌的IRR在WTC响应者中升高.
- 结肠癌和肺癌的IRR较低,其他癌症的发现是混合的,取决于参考组.
- 在使用美国人口参考数据时,仅针对前列腺癌确定了显著的时间变化点.
结论:
- 参考人群的选择对WTC暴露的人群中癌症发病率的规模,统计意义和时间趋势产生了重大影响.
- 参考组的选择会影响重大变化点的检测,强调在流行病学研究中需要仔细考虑.
- 这些发现强调了选择适当的参考人群的重要性,以便在WTC响应者和类似暴露群体中准确评估癌症风险.
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