尿酸水平与高血压患者全因死亡率之间的U形关系
Yating Huang1, Jie Li2, Feifei Sun3
1Department of Cardiology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Scientific reports
|January 2, 2025
概括
尿酸 (UA) 水平显示了高血压患者与全因死亡率的U形关联. 死亡风险在较低的UA水平下降,但在特定值以上显著增加,这些值因性别而异.
科学领域:
- 心血管医学 心血管医学
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 尿酸 (UA) 水平升高与高血压的发展有关.
- UA对高血压患者全因死亡率的影响尚不清楚.
研究的目的:
- 调查血清UA水平与高血压患者全因死亡率之间的非线性关联.
- 确定UA对死亡率的影响的性别特定值.
主要方法:
- 利用光滑曲线配合来分析非线性关系.
- 采用值和和效应分析和考克斯回归模型.
- 进行了分层分析,用于与并发病的相互作用测试.
主要成果:
- 在高血压患者中观察到UA和全因死亡率的U形曲线.
- 在男性中,死亡风险降低到7.2 mg/dL UA以下,而在7.2 mg/dL UA以上则增加.
- 在女性中,UA的保护作用低于5.1 mg/dL,而风险因子高于5.1 mg/dL.
结论:
- UA与高血压全因死亡率之间的关系是U形的.
- 存在特定于性别的拐点,表明男性和女性的风险概况不同.
- UA管理可能需要根据性别和基线水平量身定制的方法.
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