相关实验视频

Updated: Jun 4, 2025

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

对腹状条状体神经元的多巴氨基信号发送启动了嗅探行为

Natalie L Johnson¹, Anamaria Cotelo-Larrea¹, Lucas A Stetzik¹

¹Department of Pharmacology and Therapeutics, Florida Chemical Senses Institute, Center for Addiction Research and Education; University of Florida College of Medicine, Gainesville, FL, USA.

Nature communications

|January 2, 2025

概括

在腹部条纹体中释放的多巴胺驱动小鼠的嗅觉行为. 这种神经递质影响呼吸速率和多巴胺受体,揭示了激发行为和嗅觉的关键电路.

科学领域:

神经科学是一个神经科学.
行为生物学行为生物学
嗅觉研究嗅觉研究

背景情况:

嗅觉是脊椎动物的一个基本的动机行为,对嗅觉至关重要,与情感状态有关.
调节嗅探启动的神经系统及其与动机行为之间的联系在很大程度上仍未被定义.

研究的目的:

调查多巴胺在腹状条纹体中控制嗅探行为的作用.
阐明多巴胺影响呼吸速率和嗅觉发作的神经机制.

主要方法:

在小鼠体内利用电生理学和光遗传学来监测多巴胺释放和神经元活动.
操纵的多巴胺终端活性和多巴胺受体 (D1和D2) 功能在腹状条纹体中.
作为对这些操纵的反应,测量呼吸速率和嗅探频率.

主要成果:

腹腔条纹体中的多巴胺释放与嗅觉发作直接相关.
多巴胺终端的刺激增加了呼吸速率并启动了嗅觉,而抑制则减少了呼吸速率.
多巴胺受体表达神经元 (D1和D2) 的活性与嗅觉相结合,受体对抗性取消了嗅觉.

结论:

多巴胺作用于腹部条纹体神经元,启动嗅探行为.
这种由多巴胺驱动的电路将嗅觉与有动机的行为结合起来,这表明它在广泛的功能中发挥了作用.

更多相关视频

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

Published on: August 24, 2016

Examination of Rapid Dopamine Dynamics with Fast Scan Cyclic Voltammetry During Intra-oral Tastant Administration in Awake Rats

Examination of Rapid Dopamine Dynamics with Fast Scan Cyclic Voltammetry During Intra-oral Tastant Administration in Awake Rats

Published on: August 12, 2015

相关概念视频

Physiology of Smell and Olfactory Pathway

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...

Olfaction

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

Olfactory Receptors: Location and Structure

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...