乙型肝炎病毒去补偿性肝硬化患者的结果的决定因素
Yi-Jie Huang1,2, Jun-Sing Wang3,4, Cheng-Hsu Chen5,6
1Department of Public Health, College of Public Health, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist., Taichung, 406040, Taiwan.
Scientific reports
|January 2, 2025
概括
在治疗前的HBVDNA水平会影响B型肝炎病毒相关的无补偿性肝硬化症的短期生存率. 然而,年龄和肝功能储备对于这些患者的长期预后至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 临床医学 临床医学
背景情况:
- 与乙型肝炎病毒 (HBV) 相关的无补偿性肝硬化预后复杂.
- 治疗前HBVDNA水平对患者结局的具体作用尚不清楚.
研究的目的:
- 调查治疗前HBVDNA水平对短期和长期生存的影响.
- 确定慢性乙型肝炎 (CHB) 患有不补偿性肝硬化患者死亡率的其他关键决定因素.
主要方法:
- 对278名CHB患者进行了回顾性分析,这些患者患有不补偿性肝硬化症,接受了恩特卡维尔或特诺福维尔二松醇烟酸治疗.
- 考克斯回归模型被用来分析与所有原因死亡率相关的因素.
- 随访的中位持续时间为17个月,对1,3,6,12个月和60个月的死亡率进行评估.
主要成果:
- 在随访期间,全因死亡率在47.4%的患者中发生.
- 短期死亡率 (3个月) 与年龄,,肝脏脑病,肝炎发作,治疗前的HBVDNA和MELD得分有关.
- 长期死亡率 (5年) 主要与年龄,,肝脏脑病和MELD得分有关.
结论:
- 在治疗前的HBVDNA水平显著影响了不补偿性肝硬化症的短期死亡率.
- 年龄和肝功能储备 (以MELD得分表示) 是长期生存的关键决定因素.
- 在这个患者队列中,HBV DNA水平似乎不是长期死亡率的重要预测指标.
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