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富可伊丹涂层的纳米颗粒和素纳米颗粒对结直肠癌线的抗癌活性

Mohammed A Al-Duais¹, Haddad A El Rabey², Ghena M Mohammed³

¹Biochemistry Department, Faculty of Science, University of Tabuk, Tabuk, 71491, Saudi Arabia. malduais@ut.edu.sa.

Scientific reports

|January 2, 2025

概括

这项研究开发了一种新的纳米复合材料,使用纳米和纳米粒子与fucoidan. 这种天然化合物有效地抑制了结直肠癌细胞,显示了癌症治疗的前景.

科学领域:

生物技术是生物技术.
纳米医学是一种纳米医学.
癌症研究癌症研究

背景情况:

在全球范围内,结肠直肠癌的发病率和死亡率正在增加.
自然纳米粒子和海洋生物聚合物为安全有效的癌症管理提供了潜力.
黄素是一种天然化合物,具有治疗潜力,但需要增强配方.

研究的目的:

开发和评估一种新的生物活性纳米复合物 (NC),用于抑制结直肠癌 (CRC).
为了利用纳米 (NCur) 和纳米粒子 (SeNPs) 合成的富可伊丹 (Fu) 作为抗癌剂.
评估Fu/NCur/SeNPs纳米复合物对CRC细胞系的疗效.

主要方法:

纳米黄素 (NCur) 是通过使用口香糖阿拉伯语合成的.
纳米粒子 (SeNPs) 通过NCur.使用生物合成.
生物活性纳米复合材料 (NC) 的Fu/NCur/SeNPs被制造和特征使用光谱和显微镜.
在CaCo-2和HT-29细胞上进行了细胞毒性测试 (IC50) 和DNA损伤评估 (彗星测试).

主要成果:

NCur和NCur合成的SeNPs已经成功地用控制的纳米尺寸生产出来.
鉴定证实了Fu/NCur/SeNPs纳米复合物的相互作用和结合.
该Fu/NCur/SeNPs纳米复合物对CaCo-2和HT-29细胞表现出强烈的细胞毒性作用,超过了西斯.
在用纳米复合材料治疗的癌细胞中观察到显著的DNA损伤和诱导亡.

结论:

开发的Fu/NCur/SeNPs纳米复合物显示出对结直肠癌细胞具有显著的抗癌活性.
纳米复合材料有效诱导癌细胞中的DNA损伤和亡.
Fu/NCur/SeNPs的生物基性质表明它们有预防和管理结直肠腺癌的潜力.

关键词:

抗瘤行动是一项反瘤行动.生物聚合物是一种生物聚合物.生物合成生物合成结肠直肠腺癌是什么意思纳米复合材料的使用方法

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