在抗白血病反应过程中,抗原体验史指导CD8+CAR T细胞的不同功能状态

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Kole R DeGolier1,2, Etienne Danis3, Marc D'Antonio1

  • 1Department of Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Nature immunology
|January 2, 2025
PubMed
概括

之前的抗原暴露增强了化学抗原受体 (CAR) T细胞对白血病的有效性,但减少了增殖. 准RUNX转录因子可以改善CAR T细胞功能,从而改善癌症免疫疗法.

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