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甲基胺对正统牙的牙移动,正统牙诱导和非正统牙根吸收的影响? :一个微型计算机断层扫描和免疫组织化学分析
Burak Akce1, Gulay Dumanli Gok2, Sibel Demirci Delipinar3
1Department of Orthodontics, Faculty of Dentistry, Biruni University, 10. Yil Caddesi, Protokol Yolu No. 45, 34010, Istanbul, Turkey.
概括
用于ADHD的甲基酸盐可以加速正牙移动 (OTM) 并略微增加大鼠的根吸收. 较高剂量对牙运动产生更明显的影响.
科学领域:
- 生物医学科学 生物医学科学
- 药理学 药理学是指药理学的学科.
- 矯正牙科 矯正牙科是一種矯正牙科.
背景情况:
- 注意缺陷多动症 (ADHD) 通常用甲基酸盐治疗.
- 甲基酸盐对正牙移动 (OTM) 和根吸收的作用尚不清楚.
- 了解这些影响对于在服用ADHD药物时接受正牙治疗的患者至关重要.
研究的目的:
- 在大鼠模型中研究甲基酸盐对OTM的影响.
- 评估甲基酸盐在正牙治疗期间对根部再吸收的影响.
- 为了确定甲基酸对这些正参数的剂量依赖性影响.
主要方法:
- 30只大鼠被分为控制,恒定甲基胺剂量 (MCD) 和增加甲基胺剂量 (MID) 组.
- 老鼠接受了30天的盐水或甲基化物治疗,在一个子组中对牙施加了正牙力,持续了14天.
- 进行了定量微型计算机断层扫描 (micro-CT) 和免疫组织化学分析,以评估牙运动,根吸收和骨重塑标志物.
主要成果:
- 与对照组相比,高剂量的甲基酸盐显著增加了牙的移位.
- 矯正力显著增加了根的吸收,特别是在冠状区域.
- 甲基胺的使用增加了骨再吸收的标志物 (VEGF,RANK,TRAP) 和改变了OPG/RANKL的比率,这表明吸收潜力增加了.
结论:
- 在这种大鼠模型中,甲基化物显示出增强根部再吸收的弱潜力.
- 发现增加的甲基酸剂量可以加速正牙的牙移动.
- 需要进一步的研究,以充分阐明使用甲基酸盐对正牙患者的临床影响.
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