抗生素治疗的持续时间:在老年人中,更短更好吗?
Alice N Hemenway1, Caitlyn Patton1, Elias B Chahine2
11 University of Illinois Chicago College of Pharmacy, Rockford, Illinois.
The Senior care pharmacist
|January 3, 2025
概括
较短的抗生素治疗时间 (LOT) 对常见感染有效且安全,包括老年人. 这种方法可以减少抗生素耐药性,副作用和医疗费用.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 老年病的医生 老年病的医生
背景情况:
- 抗生素治疗持续时间 (LOT) 差异很大,影响耐药性,不良事件和成本.
- 随机对照试验 (RCT) 的越来越多的证据支持许多感染的较短LOT.
- 老年人在抗生素管理中存在独特的挑战,原因是改变了药理动力学和并发症.
研究的目的:
- 审查证明较短抗生素LOT对常见感染有效性的RCT.
- 具体评估较短的LOT数据对老年成人人口的适用性.
- 为优化老年患者抗生素使用提供基于证据的建议.
主要方法:
- 从精心策划的在线资源和PubMed. identified中确定RCT的系统审查.
- 根据感染类型对试验进行分类:尿道感染,肺炎,性传播感染,腹部内感染,细菌血症.
- 分析的重点是包括老年人群在内的试验.
主要成果:
- 在28个审查的RCT中,有27个支持更短的抗生素LOT.
- 证据支持更短的LOT对于复杂的尿路感染,肺炎,SSTI和阴性细菌.
- 大多数包括的试验表明了安全性和有效性,其中一些专门招募了老年人.
结论:
- 有足够的证据支持在老年患者中使用较短的抗生素LOT.
- 实施较短的LOT策略可以优化老年人群的抗生素处方.
- 这种方法有助于抗微生物药物管理,减少耐药性和医疗保健支出.
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