老年人饮食补充剂的安全性:对已发表的病例报告的审查
Alex Shahverdian1, Mahtab Jafari1
1Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, California.
The Senior care pharmacist
|January 3, 2025
概括
摄入食补充剂的老年人可能会因相互作用,高剂量或污染而出现不良事件. 医疗保健提供者在评估患者症状时应考虑补充剂.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 营养科学 营养科学
背景情况:
- 老年人经常与处方药一起使用食补充剂.
- 这种人群中补充剂使用的潜在不良事件并不总是被认可.
- 本综述侧重于病例报告,详细介绍了65岁及以上人群与食补充剂相关的不良事件.
研究的目的:
- 审查和总结最近的病例报告与饮食补充剂消费相关的不良事件在老年人.
- 确定与老年人食补充剂相关的常见原因和不良事件类型.
- 告知医疗保健提供者关于饮食补充剂对老年患者的潜在风险.
主要方法:
- 在PubMed系统搜索2000年以后发表的病例报告,使用关键词"老年人"和"食补充剂"以及相关的子标题.
- 包括来自ClinicalTrials.gov和PubMed的数据用于饮食补充剂的主要临床试验,对不良影响的查.
- 手动选了820个已识别的出版物,选择了41个相关出版物,详细介绍了46个个案例报告.
主要成果:
- 确定了46份与食补充剂相关的老年人不良事件病例报告.
- 常见的原因包括补充剂与药物相互作用,过量剂量,多种补充剂来源和污染.
- 具体的不良事件包括高血症 (维生素D),甲状腺测试干扰 (维生素B7),神经病变 (维生素B6),氧酸盐脏病变 (维生素C) 和华法林相互作用 (维生素E,K,欧米茄-3).
结论:
- 医疗保健从业者应该考虑食补充剂作为老年人不良临床表现的潜在原因.
- 鼓励患者向医疗保健提供者披露所有处方药和食补充剂.
- 鉴于老年人群中药物和补充剂使用率高,提高意识至关重要.
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