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在NIR-II激发的OFF-ON-OFF光纳米探针用于敏感的分子成像 in vivo
Yufu Tang1, Yuanyuan Li2, Chunxu He2
1Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 1, Singapore, 117585, Singapore.
Nature communications
|January 3, 2025
概括
研究人员开发了一种新型的"关闭-关闭"近红外II光探针,用于早期肝癌的敏感体内成像. 这种探测器最大限度地降低了背景噪音,使得小瘤的准确检测.
科学领域:
- 生物医学成像技术 生物医学成像技术
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 来自正常组织的背景光阻碍了早期疾病的敏感体内成像.
- 由于高纳米探针吸收,自光和深层组织深度,肝病成像具有挑战性.
研究的目的:
- 开发一种近红外II (NIR-II) 光探针,具有"关闭-关闭"特性,用于敏感的肝癌成像.
- 为了克服背景干扰,在体内早期检测疾病.
主要方法:
- 设计和合成了一种具有最小初始光度的NIR-II光探针 (NDP).
- 使用"关闭-关闭"光机制来准肝癌组织并将背景信号降到最低.
- 在小鼠中进行了盲目的研究,以评估瘤检测的准确性和灵敏性.
主要成果:
- NDP探测器呈现出接近零的初始光,在癌症组织中打开,在迁移时关闭.
- 在盲目的研究中,在识别正位肝脏瘤方面取得了100%的准确性.
- 能够灵敏地检测到早期的肝脏瘤,小到4毫米.
结论:
- "关闭"的NIR-II探针设计为早期肝癌的敏感成像提供了一个有希望的策略.
- 这种分子设计概念可以被推广到其他早期疾病病变的成像.
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