七天禁食对人类运动期间的身体表现和代谢适应的影响
Kristoffer J Kolnes1,2, Emelie T F Nilsen1, Steffen Brufladt1
1Norwegian School of Sport Sciences, Oslo, Norway.
Nature communications
|January 3, 2025
概括
七天的禁食保存了肌肉力量和氧化酶,但减少了碳水化合物氧化和耐力. 这项研究探讨了饥饿期间人类肌肉的适应性,发现了能量代谢的关键变化.
科学领域:
- 运动生理学 运动生理学
- 人类的新陈代谢.
- 营养科学 营养科学
背景情况:
- 历史上的人类饥饿需要适应生存和食物收集.
- 了解禁食期间的肌肉功能适应对人类生理学至关重要.
研究的目的:
- 研究七天禁食对人类骨肌肉功能和新陈代谢的影响.
- 检查强度,有氧能力,基质利用和关键蛋白质表达的变化.
主要方法:
- 13名参与者进行了为期7天的禁食.
- 测量包括瘦身和脂肪质量,最大的同位体和异位动力强度,氧气吸收峰值,肌肉糖原和蛋白质表达.
- 对酸盐脱酶激酶4 (PDK4) 和5'AMP激活蛋白激酶 (AMPK) 活性进行分析.
主要成果:
- 参与者减轻了瘦身和脂肪质量,但保持了最大的肌肉力量.
- 峰值氧气吸收减少了13%,肌肉糖原减少了一半,碳水化合物氧化减少了.
- PDK4的表达增加了13倍,具有抑制性pyruvate脱酶酸化,而电子运输链蛋白质保持不变.
结论:
- 骨肌肉在短期禁食期间保持强度和氧化酶表达.
- 碳水化合物氧化和高强度耐力能力显著下降.
- 禁食对AMPK活性的影响挑战了它在饥饿期间肌肉蛋白质降解中的作用.
更多相关视频
相关概念视频
Metabolic States of the Body: Fasting and Starvation
1.1K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
1.1K
Metabolic States of the Body: The Postabsorptive State
246
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
246
Exercise and Muscle Performance
1.3K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.3K
Metabolic States of the Body: The Absorptive State
649
During the absorptive state, which lasts approximately four hours after a meal, the body absorbs nutrients from the gastrointestinal tract. The carbohydrates, proteins, and lipids we consume are broken down into monosaccharides, amino acids, and free fatty acids for absorption. While carbohydrates and proteins are absorbed as-is, lipids are absorbed in their broken-down forms and then re-esterified into triglycerides within enterocytes before being packaged into chylomicrons. These absorbed...
649
Exercise and Cardiovascular Response
727
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
727


