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Updated: Jun 4, 2025

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针对与免疫透相关的肺腺癌预后模型开发和初步验证五种miRNAs

Huanzhang Yang1, Jingli Hua1, Yanxia Han1

  • 1Department of Clinical Laboratory, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.

Scientific reports
|January 3, 2025
PubMed
概括

这项研究确定了与免疫相关的microRNAs (miRNAs) 以预测肺腺癌 (LUAD) 预后和免疫治疗反应. 一个5-miRNA模型,包括miRNA-200b-3p,有助于风险分层,并表明有针对性的治疗潜力.

关键词:
生物标志物生物标志物免疫系统的透.肺部腺癌瘤是肺部腺癌.预测 预后 预测 预测微RNA-200b-3p-3p是什么意思

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MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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