系统性免疫炎症指数和中风之间的关联:NHANES (2015-2020) 的基于人口的研究
Rui Shi1,2, Ye Tian3, Junbiao Tian4,5
1Graduate School of Hebei University of Chinese Medicine, Shijiazhuang, 050091, Hebei, China.
Scientific reports
|January 3, 2025
概括
系统性免疫-炎症指数 (SII) 与中风患病率有积极联系. 较高的SII水平可能表明中风风险增加,需要进一步调查.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 系统性免疫-炎症指数 (SII) 是一种反映炎症反应的新型复合标志物.
- 炎症在中风的病理生理学中起着至关重要的作用.
研究的目的:
- 调查系统性免疫-炎症指数 (SII) 与中风患病率之间的关联.
- 探索SII作为中风风险生物标志物的潜力.
主要方法:
- 从2015-2020年国家健康和营养检查调查 (NHANES) 中对13,287名参与者的横截面分析.
- 使用多变量线性回归模型来评估SII-中风相关性.
- 使用平滑曲线和值效应分析来检查非线性关系.
主要成果:
- 在SII和中风发病率之间发现了显著的积极关联 (OR [95% CI]:1.02 [1.01, 1.04],P < 0.01).
- 确定了一个非线性关系,折叠点为740 (1,000细胞/μl).
- 积极的关联在各种人口和临床子组中保持一致.
结论:
- 系统性免疫-炎症指数 (SII) 水平的升高与中风患病率的增加有关.
- 需要进一步的大规模前性研究来验证这些发现并阐明因果关系.
更多相关视频
12:42Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia
Published on: December 28, 2014
15.6K
07:26Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery
Published on: May 24, 2021
7.0K
相关概念视频
01:27Psychoneuroimmunology: Cardiovascular Disease
25
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
25
01:38Inflammation
52.5K
Overview
52.5K
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
56
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
56