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在代谢功能障碍相关的脂肪肝疾病中,对甘油三指数和相关参数的相关性分析

Xin Yang¹, Huiting Rao¹, Yi Yuan²

¹Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Street Taiping No.25, Region Jiangyang, Luzhou, 646099, Sichuan, China.

Scientific reports

|January 3, 2025

概括

甘油三糖指数 (TyG) 和相关参数显示,与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 有着强烈的相关性. 这些标志物有效预测MAFLD风险,特别是在特定的人口群体中.

科学领域:

代谢综合征是代谢综合征的一种.
肝病学肝病学是一种肝病学.
生物标志物生物标志物

背景情况:

与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一个日益严重的健康问题.
早期检测和风险分层对于管理MAFLD至关重要.
甘油三糖指数 (TyG) 是一种潜在的胰岛素耐药性的指标.

研究的目的:

调查TyG指数和相关参数与MAFLD之间的相关性.
评估TyG指数的预测值及其对MAFLD的修改.
探索剂量反应关系和TyG和MAFLD风险之间的非线性关联.

主要方法:

对71,299名接受健康检查和腹部超声波的人进行了回顾性研究.
单变量和多变量逻辑回归分析以评估相关性.
对于非线性关系的限制立方线 (RCS) 分析.
接收器操作特征 (ROC) 曲线分析以确定预测值 (AUC).

主要成果:

泰格指数和相关参数 (泰格-BMI,泰格-WC,泰格-WHR) 与MAFLD正相关.
在TyG和MAFLD风险之间观察到显著的剂量反应关系.
ROC分析显示了大量的预测值:TyG (AUC=0.83),TyG-BMI (AUC=0.92),TyG-WC (AUC=0.90),TyG-WHR (AUC=0.87). 在这些数据中,TyG-BMI (AUC=0.92),TyG-WC (AUC=0.90) 和TyG-WHR (AUC=0.87) 均为可预测值.
预测值在女性,年轻人以及BMI<23.7.7的个体中更高.

结论:

泰格指数及其修改形式是MAFLD的有价值指标.
这些标志物显示出对MAFLD发展具有显著的预测能力.
这些发现支持使用基于TyG的指数进行MAFLD风险评估,特别是在风险人群中.

关键词:

相关性分析是一项相关性分析.马夫尔德 (MAFLD) 是一个 TyG和相关参数的相关参数.

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