在肥胖儿童中,肠道微生物群和短链脂肪酸之间的关联
Shihan Li1, Xinyu Ma2, Hong Mei3
1Department of Child Healthcare, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, 100 Hongkong Road, Wuhan, 430016, Hubei, China.
Scientific reports
|January 3, 2025
概括
儿童肥胖与肠道细菌的变化有关,特定的细菌和短链脂肪酸 (SCFA) 如丁酸盐和酸盐发生变化. 这些肠道微生物组的变化影响了儿童的新陈代谢和肥胖发展.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 儿科健康 儿科健康
背景情况:
- 肠道微生物组在调节肥胖病原发生方面发挥着至关重要的作用.
- 了解肥胖儿童的肠道微生物群和代谢物概况对于有针对性的干预措施至关重要.
研究的目的:
- 描述肥胖儿童的肠道微生物组和短链脂肪酸 (SCFA) 代谢组.
- 确定与儿童肥胖相关的特定微生物和代谢特征.
主要方法:
- 病例控制研究比较肥胖 (OG) 和正常 (NG) 儿童 (7-14岁).
- 整基因组射击枪元基因组测序用于肠道微生物群分析.
- 高性能液体染色学/质谱学 (LC/MS) 用于血清代谢物分析.
主要成果:
- 增加了蛋白质细菌的丰富性,并在原始基因中降低了奥西利巴克特/阿利斯蒂普在属级别的数量.
- 在肥胖儿童中增加了酸盐和降低了酸盐/异酸盐水平.
- 丰富的KEGG通路包括转移酶系统 (PTS) 和Escherichia coli在OG中的生物膜形成.
结论:
- 儿童肥胖与肠道微生物群组成和SCFA概况的改变有关.
- 奥西利巴克特属和特定的SCFA与儿童肥胖密切相关.
- 肠道微生物群通过特定途径影响宿主的新陈代谢,有助于肥胖的发展.
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