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带有EP300突变的食道状细胞癌表现出与新辅助化学放射治疗相关的独特遗传特征
Yutian Lai1,2, Yingxian Dong1,2, Long Tian1,2
1Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P.R. China.
World journal of surgical oncology
|January 3, 2025
概括
食道癌中的EP300突变与新辅助化学放射治疗 (nCRT) 的反应不佳有关,这是由于高免疫活性和抗亡. 这些突变预测ESCC患者的生存结果更差.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 癌症研究 癌症研究
背景情况:
- 在食道状细胞癌 (ESCC) 中,EP300突变很普遍.
- 了解EP300突变对治疗反应和预后的影响对于ESCC管理至关重要.
研究的目的:
- 研究EP300突变对ESCC患者新辅助化学放射治疗 (nCRT) 疗效的影响.
- 分析EP300突变状态,瘤微环境和患者存活率之间的关系.
主要方法:
- 分析了接受nCRT的30名ESCC患者.
- 对具有良好或不良治疗反应的患者的样本进行了转录组分析和免疫组织化学分析.
- 评估了免疫分数,B细胞透和bcl2表达.
主要成果:
- 四名EP300突变患者对nCRT反应不佳.
- 与野生型低响应者相比,EP300突变的低响应者表现出更高的免疫评分和增加的B细胞活性.
- EP300突变的低响应者也表现出更高的抗亡活性 (bcl2表达) 和更差的无疾病和整体存活率.
结论:
- 在ESCC中EP300突变与瘤微环境中的免疫活性增加有关.
- 在EP300突变瘤中增加的抗亡机制可能会导致对nCRT的抗性.
- 在ESCC中,EP300突变状态作为预测治疗反应和预后的潜在生物标志物.
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