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针对食物过敏的皮肤上免疫疗法:系统性审查和元分析

Xiaohong Xiang¹, Jingwei Hu², Rangui Sachu³

¹Department of Pediatric, Affiliated Chifeng Clinical College of Inner, Mongolia Medical University, Chifeng, China.

Systematic reviews

|January 3, 2025

概括

皮肤上免疫疗法 (EPIT) 有效地提高了对食物过敏的免疫耐受性,特别是在儿童中. 然而,EPIT还增加了过敏反应和局部皮肤反应的风险,需要进一步研究.

科学领域:

过敏和免疫学过敏和免疫学
皮肤病学皮肤病学
临床试验临床试验

背景情况:

关于皮肤上免疫疗法 (EPIT) 治疗食物过敏的安全性和有效性,目前仍存在争论.
EPIT涉及将过敏原应用于皮肤表面以诱导耐受性.

研究的目的:

系统地审查并进行元分析,评估EPIT在食物过敏患者的安全性和有效性.
评估结果,包括脱敏,不良事件和生活质量.

主要方法:

在多个数据库 (PubMed,Embase,CENTRAL,Web of Science,ClinicalTrials.gov) 进行系统搜索,直到2023年6月25日.
包括10项高质量的随机对照试验 (RCT),重点关注花生和牛奶过敏.
使用Cochrane ROB 2工具进行偏见风险评估,并通过GRADE方法评估证据的确定性.

主要成果:

EPIT促进了食物过敏患者的脱敏 (RR 2.11),特别是在年龄小于11岁 (RR 3.84) 的患者中.
治疗持续时间≥52周增加了免疫耐受性 (RR 3.37).
EPIT增加了局部 (RR 1.63,低确定性) 和全身不良反应 (RR 1.52,高确定性),包括轻度至中度过敏反应.

结论:

EPIT可以有效地提高对食物过敏原的免疫耐受性.
EPIT与轻度至中度过敏反应的发病率增加有关.
需要进一步的研究来了解EPIT对生活质量和其他过敏状况的影响.

关键词:

皮肤上的免疫疗法 (Epicutaneous Immunotherapy) 是一种皮肤上的免疫疗法.食物过敏食物过敏进行元分析.系统审查是系统的审查.

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