FTO rs1121980 多态性导致汉族中国人群冠状动脉病易感性
Xue Min1, Yu-Lan Zhou1,2, Yun-Fei Qu1
1Dongguan Key Laboratory of Aging and Anti-Aging, Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, Cardiovascular Center, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523808, P.R. China.
Lipids in health and disease
|January 3, 2025
概括
FTO rs1121980基因变异增加了冠状动脉疾病 (CAD) 和心肌梗塞 (MI) 的风险. 这种联系在年轻人中更强烈,与改变的甘油三和高密度胆固醇水平有关.
科学领域:
- 遗传学和心血管疾病
- 分子生物学和疾病机制
背景情况:
- 脂肪质量和与肥胖相关的蛋白质 (FTO) 基因与冠状动脉疾病 (CAD) 病原发生有关.
- FTO遗传变异对CAD风险的具体影响需要进一步调查.
研究的目的:
- 调查FTO基因多态 (rs1121980,rs72803657,rs4783818) 和对冠状动脉疾病 (CAD) 的易感性之间的关联.
- 探索这些FTO变体与中国队列中的脂质样本之间的关系.
主要方法:
- 在712个CAD病例和701个对照中使用PCR-LDR进行了三种FTOSNP (rs1121980,rs72803657,rs4783818) 的基因定型.
- 使用多变量逻辑回归,对SNP与CAD和心肌梗塞 (MI) 的关联进行统计分析.
- 通过Kruskal-Wallis或Wilcoxon-Mann-Whitney测试评估SNP与脂质样本的关联.
主要成果:
- FTO rs1121980的A等位基因和AA基因型与增加的CAD风险 (OR=1.26,P=0.044;OR=3.13,P=0.002) 和MI风险 (OR=1.54,P=0.002;OR=5.61,P<0.001) 显著相关.
- 没有发现rs72803657和rs4783818与CAD或MI有显著的关联.
- 在年轻,不吸烟和不饮酒的人群中,rs1121980的关联更为明显,携带者表现出较高的甘油三和较低的HDL-C.
结论:
- FTO rs1121980多态性是中国人群中CAD的危险因素.
- 这种关联在年轻人中尤为显著,可能由脂质障碍症 (高甘油,降低HDL-C) 介导.
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