性差异,与月经有关的症状和更年期在肠-大脑相互作用障碍中的症状
Rachel P Sarnoff1, Johann P Hreinsson2, Joanna Kim1
1University of California Los Angeles David Geffen School of Medicine, California, Los Angeles, USA.
Neurogastroenterology and motility
|January 3, 2025
概括
女性比男性更容易患上肠-大脑相互作用障碍 (DGBI). 更年期会影响症状,更年期前的妇女表现出更高的内脏感知,而更年期后的妇女则经历了更多的出口功能障碍.
科学领域:
- 胃肠病学 胃肠病学
- 妇科 妇科 妇科 妇科
- 流行病学 流行病学
背景情况:
- 肠-大脑相互作用障碍 (DGBI) 在女性中更为普遍.
- 在DGBI内对与月经有关的或更年期症状的性别差异的理解有限.
研究的目的:
- 评估罗马IV DGBI症状中的性别和更年期状态差异.
- 调查与月经有关的和与更年期相关的症状变异.
主要方法:
- 利用罗马基金会全球流行病学调查 (14,570名参与者) 的数据.
- 评价 5 罗马四号 DGBI:IBS,FD,FC,FDr,FB. 评价了
- 使用后勤回归和标准化平均差异 (SMD) 来分析性别和更年期差异.
主要成果:
- 与男性相比,女性在5个DGBI中报告了更高的症状频率.
- 绝经前妇女出现便秘症状增加 (IBS,FD,FC).
- 绝经后的妇女增加了意外便泄漏 (IBS,FDr) 和数字手动操作 (FC).
结论:
- 女性表现出比男性更高的DGBI症状频率.
- 绝经前妇女可能有更大的内脏感知;绝经后妇女显示增加了直肠/盆腔功能障碍.
- 女性性激素可能会影响DGBI的内脏感知.
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