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通过特定的饮食成分在人性化小鼠模型中准狼性疾病的进展

Nikola Ralchev¹, Lidiya Kechidzhieva¹, Blagovesta Boneva¹

¹Laboratory of Experimental Immunology, Department of Immunology, The "Stephan Аngeloff" Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, 1113, Bulgaria.

Molecular nutrition & food research

|January 3, 2025

概括

补充一种富含甲基供体的特殊饮食,以人性化小鼠的系统性红斑狼 (SLE) 减少疾病标志物. 这表明通过调节免疫细胞基因表达来治疗SLE的潜在治疗策略.

科学领域:

免疫学免疫学免疫学
自免疫性疾病自免疫性疾病
遗传学是一个遗传学.

背景情况:

系统性红斑狼 (SLE) 是一种复杂的自身免疫性疾病,其特征是免疫系统失调.
鼠标模型,包括与患者免疫细胞移植的人性化模型,对于理解SLE病变和开发治疗方法至关重要.

研究的目的:

在SLE的人性化小鼠模型中研究甲基捐赠者丰富饮食的治疗潜力.
在SLE的背景下,探索甲基捐赠体对免疫细胞的免疫调节作用.

主要方法:

人性化的NSG/Rag2-γc-小鼠被植入来自SLE患者的外周血液单核细胞 (PBMC).
给小鼠食的是对照饮食或补充含甲基微量营养素和辅助因子的饮食.

主要成果:

补充饮食显著降低了抗dsDNA IgG抗体水平和蛋白尿.
在补充饮食的小鼠中观察到减少了球增殖和保护脏结构.
与DNA甲基化和免疫细胞中向基因表达抑制的潜在变化相关的治疗效应.

结论:

在人性化的SLE模型中,甲基供体具有显著的免疫调节特性.
与甲基捐赠体的食补充剂代表着SLE具有临床潜力的有前途的治疗途径.

关键词:

通过DNA甲基化.饮食饮食饮食饮食表观遗传学是指表观遗传学.人性化模型的人性化模型免疫调节的免疫调节

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