儿童和青少年样本中的亚临床目标器官损伤与孤独的功能脏. 一个试点研究研究
Angela Tagetti1, Filippo Cattazzo1, Denise Marcon1
1Department of Medicine.
Journal of hypertension
|January 3, 2025
概括
患有单一功能脏的儿童和青少年面临高心血管风险,往往带有掩盖的高血压. 早期发现血压问题和亚临床器官损伤对于及时干预和监测至关重要.
科学领域:
- 儿科 儿科 儿科
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 孤独的功能与心血管风险增加有关.
- 在这个人群中,亚临床心血管器官损伤可能很普遍.
研究的目的:
- 评估周围和中心血压对亚临床心血管器官损伤的影响.
- 评估儿童和青少年患有单独功能脏的心血管风险.
主要方法:
- 冠状动脉超声波 (cIMT,延展性),度计 (PWV),心声图 (心脏质量/重塑).
- 办公室和24小时的门诊血压 (BP) 监测.
- 分析中心缩血压 (cSBP) 和其与器官损伤的关联.
主要成果:
- 在24小时ABPM中,高血压 (45%) 和掩盖高血压 (43%) 的高患病率.
- 在52%的患者中增加了动脉内心介质厚度 (cIMT),在43%的患者中增加了心脏重塑.
- cSBP与cIMT和左心室质量指数正相关,独立地与增加的cIMT相关.
结论:
- 患有孤独性功能儿童/青少年有高率的掩盖高血压和亚临床心血管损伤.
- 建议24小时ABPM用于识别需要高血压治疗和监测的高风险患者.
- 在这个队列中,cSBP测量应该是心血管风险评估的一部分.
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