与 gabapentinoids 相关的精神疾病:基于FAERS数据库的分析,从2004年到2023年
Jingjing Li1, Zhicheng Dai2, Zhengwei Zhang3
1Department of Neonatal, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Expert opinion on drug safety
|January 3, 2025
概括
像 gabapentin 和 pregabalin 这样的 gabapentinoids 与增加的精神疾病有关,包括焦虑和自杀念头. 这项对FDA数据的分析突出了需要进一步调查的重大安全问题.
科学领域:
- 药物监督 药物监督 药物监督
- 神经科学是一个神经科学.
- 临床药理学 临床药理学
背景情况:
- gabapentinoids (gabapentin,pregabalin) 是广泛用于治疗神经病痛的药物.
- 越来越多地认识到与 gabapentinoid 使用相关的安全问题.
- 这项研究调查了与 gabapentinoids 相关的精神病不良事件.
研究的目的:
- 分析美国FDA不良事件报告系统 (FAERS) 数据库.
- 评估精神疾病的风险作为 gabapentinoids 的不良影响.
- 为了比较加巴丁和普雷加巴林的精神病学不良事件概况.
主要方法:
- 在FAERS数据 (2004-2023) 上使用ROR,PRR,BCPNN和MGPS进行不成比例分析.
- 卡普兰-梅尔和日志等级测试用于发病率和发病分析.
- 对死亡率和住院率进行奇平方测试.
主要成果:
- 在174,321份不良事件报告中,超过22%涉及精神疾病.
- gabapentinoids 与精神疾病的发病率增加有关,包括焦虑和自杀念头.
- 在 gabapentin 和 pregabalin 之间观察到发生率和健康结果的显著差异.
结论:
- gabapentinoid 使用与精神疾病之间存在明显的相关性.
- 进一步的研究是有必要的,以了解潜在的机制.
- 制定这些不良影响的预防策略至关重要.
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