痴呆症风险症状与唐氏综合征成人功能活动的关联
Selena E Washington1, Amy E Bodde2, Brian C Helsel3
1Department of Occupational Science and Occupational Therapy Saint Louis University St. Louis Missouri USA.
Alzheimer's & dementia (New York, N. Y.)
|January 3, 2025
概括
患有唐氏综合征 (DS) 的成年人随着年龄的增长会增加痴呆症的风险. 身体功能受损和日常生活的独立性与DS中更高的痴呆风险症状有关.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 遗传学 是一个遗传学.
背景情况:
- 患有唐氏综合征 (DS) 的成年人患阿尔茨海默氏症 (AD) 痴呆症的风险明显更高.
- 与阿尔茨海默氏症相关的神经病理变化可以在40岁左右的阿尔茨海默氏症患者中显现.
- 身体功能和日常生活活动 (ADLs) 是关键的,但研究不足的方面,可以预测这个人群的痴呆风险.
研究的目的:
- 为了调查身体功能 (步态,平衡,力量),ADLs和痴呆症风险症状在成年人与DS之间的关联.
- 为了确定ADL中较差的身体功能和减少的独立性是否与痴呆症风险指标的增加相关.
主要方法:
- 一项横截面研究分析了43名患有DS的成年人的数据 (平均年龄为30±12岁).
- 痴呆症风险症状使用智力障碍患者痴呆症查问卷 (DSQIID) 进行评估.
- 身体功能通过定时上升和移动 (TUG),坐立 (STS) 测试和握力测量,以及每日生活规模的韦斯曼活动 (Waisman ADL) 测量.
主要成果:
- 较高的DSQIID分数 (表明更高的痴呆风险) 与ADL的独立性较低有关 (β = -0.103,p = 0.008).
- 痴呆症风险增加与慢步 (TUG; β = 0.112,p = 0.034),下肢强度受损 (STS; β = 0.112,p = 0.017) 和握力减弱 (β = -0.039,p = 0.034) 相相关.
- 30岁及以上的参与者在DSQIID上得分明显高于30岁以下的参与者,这表明与年龄相关的痴呆风险.
结论:
- 患有痴呆症的成年人的痴呆症风险症状与年龄的增长,身体功能减弱和ADL的独立性降低有关.
- 这些发现表明,身体功能下降和ADL可能是唐氏综合征成年人随后痴呆风险的早期指标.
- 需要进行长度研究,以确认这个人群中身体功能,ADL独立性和痴呆症风险之间的因果关系.
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