评估两种活体减弱疫苗对抗Salmonella enterica血清阅读在火:减少组织殖民和桃体转录组反应
Melissa S Monson1, Manoj Gurung1,2, Bradley L Bearson3
1Food Safety and Enteric Pathogens Research Unit, National Animal Disease Center, U.S. Department of Agriculture-Agricultural Research Service (USDA-ARS), Ames, IA, United States.
Frontiers in veterinary science
|January 3, 2025
概括
两种沙门氏菌疫苗减少了火的殖民和脏传播. 这两种疫苗也限制了在沙门氏菌阅读挑战后桃体中基因表达的变化.
科学领域:
- 兽医免疫学 兽医免疫学
- 食品安全 食品安全
- 禽畜科学是一门学科.
背景情况:
- 新出现的沙门氏菌 (Salmonella enterica serovar) 阅读 (S.阅读) 对火产业构成重大威胁.
- 需要有效的疫苗来控制S.阅读在家禽生产中的疫情.
研究的目的:
- 评估内部开发和商业化活体减弱型沙门氏菌疫苗对火S. Reading的疗效.
- 评估疫苗接种对沙门氏菌殖民,传播和宿主基因表达的影响.
主要方法:
- 土耳其被接种疫苗 (口服或气溶) 或模拟接种疫苗.
- 鸟类在7周大时受到S.阅读的挑战.
- 分析了沙门氏菌的殖民化,脏的传播和桃体的基因表达.
主要成果:
- 接种疫苗的火显示S.阅读殖民性显著减少 (1.5-3 log10 CFU/g) 在内含量和桃体.
- 这两种疫苗都显著减少了沙门氏菌向脏的传播.
- 疫苗接种减轻了肠道载体和桃体中结蛋白的转录变化.
结论:
- 两种评估的沙门氏菌疫苗都显示出针对火中的S. Reading的交叉保护功效.
- 疫苗接种减少了细菌负载和系统传播,并调节了宿主基因反应.
- 这些发现支持使用这些疫苗来控制家禽中的S.阅读.
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