胆性对早产双胞胎神经发育结果的影响
Catarina Leuzinger Dias1, Catarina Cordeiro1, Margarida Camacho-Sampaio1
1Neonatology Department, Maternidade Bissaya Barreto, Unidade Local de Saúde de Coimbra, Coimbra, PRT.
Cureus
|January 3, 2025
概括
胆性并没有显著影响早产双胞胎的神经发育结果. 妊娠年龄和出生体重是避免这些高风险婴儿神经发育障碍的关键预测因素.
科学领域:
- 新生儿医学 新生儿医学
- 发育儿科 发育儿科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 在全球范围内,多胎妊娠正在增加,双胞胎怀孕带来更高的早产和新生儿并发症风险.
- 与二双胞胎相比,单双胞胎的不良结果风险更大.
- 了解影响早产双胞胎神经发育结果的因素对于改善长期健康至关重要.
研究的目的:
- 为了研究表性对早产双胞胎神经发育结果的影响.
- 在这个弱势群体中确定神经发育障碍的预测因素.
- 为双胞胎怀孕的临床管理策略提供信息.
主要方法:
- 对早产双胞胎 (出生小于32周的GA和/或小于1500g) 进行回顾性队列研究,这些双胞胎被录入NICU (2013-2021年).
- 在24个月使用格里菲斯II心理发展尺度对神经发育结果进行评估,并对年龄进行了校正.
- 中度至重度的神经发育障碍 (NDI) 定义为全球发育系数<70,严重的视力障碍,脑或深刻的感觉神经耳聋.
主要成果:
- 分析了125名早产双胞胎,其中45%是单胆子双胞胎.
- 总体NDI率为5.6%,受影响婴儿的并发病率较高.
- 单胆双胞胎和双胆双胞胎之间的NDI或并发症没有显著差异.
- 怀孕年龄>27周和出生体重>1010g预计没有中度至重度的NDI.
结论:
- 单独的胆性并不独立地影响早产双胞胎的神经发育结果,当并发症得到管理时.
- 有效的产前监测和治疗,特别是单胎妊娠,至关重要.
- 怀孕年龄和出生体重是预测早产双胞胎神经发育轨迹的重要指标.
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