孕产妇Graves'疾病对新生儿甲状腺功能的影响:一个系统性审查
Maria Tzoraki1, Grigorios Karampas2, Antigoni Sarantaki3
1Medical Service Department, Hygeia Hospital, Athens, GRC.
Cureus
|January 3, 2025
概括
孕产妇格雷夫斯病 (GD) 可以通过抗体转移影响新生儿甲状腺功能. 早期查孕产妇的铁激素受体抗体 (TRAbs) 和新生儿检测对于管理结果至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 新生儿科学 新生儿科学
- 产科 产科 产科 产科 产科
背景情况:
- 孕产妇的格雷夫斯病 (GD) 对新生儿的甲状腺功能存在风险,原因是甲状腺受体抗体 (TRAbs) 的胎盘转移.
- 了解母亲GD及其治疗对新生儿甲状腺状况的影响对于优化婴儿健康结果至关重要.
研究的目的:
- 系统地审查母亲GD对新生儿甲状腺结果的影响.
- 在GD的背景下,确定影响新生儿甲状腺功能障碍的母亲因素.
主要方法:
- 在PubMed,Scopus和Cochrane进行了系统的文献搜索.
- 包括18项研究 (2014-2024年),重点关注患有活跃或先前GD和母亲治疗 (ATD,RAI,甲状腺切除术) 的母亲所产生的新生儿.
主要成果:
- 母体TRAb水平升高强烈预测新生儿甲状腺功能障碍 (甲状腺功能障碍,过渡性甲状腺毒性,甲状腺功能障碍).
- 新生儿甲状腺功能障碍的发病率在0.1%至5%之间,在长期使用抗甲状腺药物 (ATD) 的怀孕中发病率更高.
- 新生儿的结局不同,需要对发育风险进行监测,尽管通常有利于及时诊断和治疗.
结论:
- 第三个月的早期TRAb查和新生儿甲状腺功能测试至关重要.
- 需要标准化的协议来管理由GD复杂的怀孕,以优化新生儿的结果.
- 对长期神经发育结果和母亲治疗影响的进一步研究是有必要的.
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