系统性炎症生物标志物的预测价值,用于预测经皮膜瘤切除术后的术后系统性炎症反应综合征
Qi Wei1,2, AiMin Liu2, ZhiYong Sun2
1Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China; Anhui Medical University and Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, People's Republic of China.
International journal of general medicine
|January 3, 2025
概括
手术前的中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR) 和全身免疫炎症指数 (SII) 预测皮肤透神经切除术 (PCNL) 后的全身炎症反应综合征 (SIRS). 这些生物标志物有助于风险分层,以改善患者管理.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 外科手术炎症 在外科手术炎症.
- 生物标志物研究 生物标志物研究
背景情况:
- 系统性炎症响应综合征 (SIRS) 是皮肤透神经切除术 (PCNL) 后的一种潜在并发症.
- 确定SIRS可靠的预测因子对于优化患者的治疗结果和术后管理至关重要.
- 系统性炎症生物标志物,包括NLR,LMR,PLR和SII,在各种炎症条件中显示出潜力.
研究的目的:
- 评估中性粒细胞与淋巴细胞比率 (NLR),淋巴细胞与单细胞比率 (LMR),血小板与淋巴细胞比率 (PLR) 和系统性免疫炎症指数 (SII) 对PCNL后SIRS发生的预测意义.
主要方法:
- 对接受PCNL的317名患者的回顾性分析,分为SIRS (n=51) 和非SIRS (n=266) 组.
- 评估NLR,LMR,PLR和SII,以及人口和手术因素,作为SIRS的潜在预测因素.
- 应用单变量和多变量逻辑回归,以及接收器运行特征 (ROC) 曲线分析.
主要成果:
- 与非SIRS组相比,SIRS组的NLR,PLR和SII显著增加.
- 多变量分析确定了NLR (OR=1.292),PLR (OR=1.008) 和SII (OR=1.001) 作为PCNL后SIRS的独立预测因素.
- 经过ROC分析,NLR (AUC=0.638),PLR (AUC=0.644) 和SII (AUC=0.680) 的区分能力得到了证明.
结论:
- 手术前的NLR,PLR和SII是预测PCNL后SIRS风险的有价值指标.
- 这些生物标志物可以帮助识别高风险患者,使得手术前评估和治疗策略能够量身定制.
- 进一步的研究可以探索将这些炎症标志物整合到PCNL患者的常规术前评估中.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
37
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
37
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
63
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
63