来自Portulaca oleracea L. 的两个新染色体及其生物活性
Zheming Ying1, Kaiyun Jiang1, Jing Liu2
1School of Traditional Chinese Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, P.R. China.
Natural product research
|January 3, 2025
概括
从Portulaca oleracea L.中分离的两个新化合物 - - oleracone H和oleracone I - - 显示出强大的抗氧化和抗炎活性. 这些天然化合物有效地清除DPPH基,并抑制关键炎症因子IL-1β和TNF-α.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 药用化学 医学化学
背景情况:
- 葡萄 (Portulaca oleracea L.) 是一个广泛分布的植物,有着传统医疗用途的历史.
- 染色体是一种有机化合物的类别,以各种生物活动而闻名,包括抗氧化和抗炎性质.
研究的目的:
- 从Portulaca oleracea L.中分离和描述新的染色体化合物.
- 评估分离化合物的抗氧化和抗炎潜力.
主要方法:
- 使用紫外线,红外线,UHPLC-ESI-QTOF/MS,1D NMR,2D NMR和CD光谱学对化合物的隔离和结构阐明.
- 通过1,1-二-2-皮克里尔-化 (DPPH) 基质清除试验评估抗氧化活性.
- 通过测量抗白素-1β (IL-1β) 和瘤亡因子-α (TNF-α) 的抑制来评估抗炎作用.
主要成果:
- 两种新型染色体 - - oleracone H (1) 和 oleracone I (2) 成功被分离和鉴定出来.
- 这两种化合物都表现出显著的DPPH激素清除活性,Oleracone H的IC50值为16.33 ± 0.20 μM,Oleracone I的IC50值为22.36 ± 0.41 μM.
- 与10μM度的阳性对照相比,奥莱拉H和奥莱拉I显示出较强的IL-1β和TNF-α炎症因子抑制.
结论:
- 奥莱拉康H和奥莱拉康I是来自Portulaca oleracea L.的新染色体衍生物,具有有前途的抗氧化和抗炎性质.
- 这些发现表明,这些化合物可以作为与氧化应激和炎症相关的条件的潜在治疗剂.
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