内分子排斥性相互作用使NIR-II聚合诱导发射光原体的高效率成为可能,用于高对比度质母细胞瘤成像
Fulong Ma1, Zhiyuan Gao2, Qian Jia1,3
1Clinical Translational Research Center of Aggregation-Induced Emission, School of Medicine, The Second Affiliated Hospital, School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong 518172, China.
ACS nano
|January 3, 2025
概括
研究人员通过加强排斥性相互作用开发了新的近红外II (NIR-II) 发射器,克服了更明亮发光的能量差距法则. 这一突破使得增强生物成像和质母细胞瘤检测成为可能.
科学领域:
- 有机化学 有机化学
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 为第二次近红外 (NIR-II) 窗口 (1000-1700 nm) 开发高效的光源是具有挑战性的,因为能量差距法则限制了生物成像中的应用.
- 无辐射无活化途径往往阻碍在有机材料中实现高发光效率.
研究的目的:
- 通过操纵排斥性相互作用,开创一种提高NIR-II发射器发光效率的战略.
- 研究这些相互作用对分子性质和发光性能的影响.
- 证明这些新型NIR-II发光剂在高对比度生物成像中的实用性,特别是用于质母细胞瘤检测.
主要方法:
- 合成了NIR-II发光剂,通过引入大体积的负载来加剧电子密度之间的排斥相互作用.
- 使用测量坐标移位,重组能量和内部转换率的技术,对合成材料进行了表征.
- 评估的发光效率,聚合诱导发射 (AIE) 活动,以及从分子到聚合状态的光发射.
- 功能化的NIR-II纳米颗粒与向大脑向质母细胞瘤成像的向性酸.
主要成果:
- 强化的排斥性相互作用显著抑制了无辐射失活,导致发光效率增加了3.8倍.
- 观察到坐标移位和重组能量的减少,证实了非辐射衰变的抑制.
- 在聚合物中实现了高度扭曲的分子构造,优越的AIE活性和级联光增强.
- 通过使用功能化NIR-II纳米颗粒,证明了正位体质母细胞瘤的准确检测和高对比成像.
结论:
- 强化排斥性相互作用的策略提供了一个基本的方法来克服能效NIR-II发光剂的能量差距法.
- 开发的NIR-II光体具有出色的光物理性能,包括高效率和AIE特征.
- 功能化的NIR-II纳米颗粒显示出在高对比度生物成像和早期质母细胞瘤检测中具有先进应用的巨大潜力.
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