在患有多发性硬化症的人群中,COVID-19感染的后急性继发
Amber Salter1,2, Samantha Lancia1, Gary R Cutter3
1Department of Neurology, Section on Statistical Planning and Analysis, UT Southwestern, Dallas, TX, USA.
Multiple sclerosis (Houndmills, Basingstoke, England)
|January 3, 2025
概括
后急性继发症 (PASC) 症状与多发性硬化症 (MS) 发生重叠. 这项研究发现,MS患者的PASC患病率低于预期,常见症状使评估复杂化.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 在SARS-CoV-2感染后的急性后续症状 (PASC) 与多发性硬化症 (MS) 症状有相似之处.
- 针对普通人群开发的PASC评分在MS患者中进行了评估,这些患者有不同的感染史.
研究的目的:
- 研究患有多发性硬化症的个体中PASC的患病率和特征.
- 根据感染史,评估PASC得分在多发性硬化症队列中的有用性.
主要方法:
- 来自北美多发性硬化症研究委员会 (NARCOMS) 登记册的受访参与者.
- 根据感染史分类参与者 (COVID-19,非COVID-19,两者,或未感染).
- 根据持续的新症状和NIH RECOVER研究标准的12分或更高的得分来定义PASC.
主要成果:
- 在2927名参与者中,10%的参与者最近有COVID-19,29.1%的参与者最近没有COVID-19,8.4%的参与者有两种情况,52.4%的参与者没有感染.
- 与未感染个体相比,感染组报告发烧,咳和嗅觉/味觉丧失等症状增加了两倍.
- 根据持续的新症状,PASC仅在1.5%的COVID-19参与者中被发现.
结论:
- 该研究表明,在多发性硬化症患者中,PASC的患病率低于预期.
- 感染和感染后出现新的持续性症状之间存在复杂的关系.
- 在不同感染群体中PASC症状的共同性使得在MS患者中精确的PASC评估变得复杂.
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