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Updated: Jun 4, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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针对DNA四面体驱动的多价值蛋白解化基因组:提高蛋白质降解效率和瘤向

Shiqing Li1, Tao Zeng1, Zhixing Wu1

  • 1New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou 350108, People's Republic of China.

Journal of the American Chemical Society
|January 3, 2025
PubMed
概括

DNA四面体链接器创建了针对癌症治疗的新型多价值蛋白质解体仿真体 (PROTAC). 这种新平台有效准和降解像STAT3这样的瘤相关蛋白质,在临床前模型中显示出优异的抗瘤活性.

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