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Updated: Jun 28, 2026

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使用原水解剂进行增强的无基生产:一种具有成本效益和高效率的合成策略

Xia Li1,2,3, Xian Liu1, Ming Yang1

  • 1College of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China.

Journal of materials chemistry. B
|January 3, 2025
PubMed
概括

原水解剂增强了Streptomyces的无原素 (UDP) 生产,显著增加了产量并减少了发酵时间. 这种具有成本效益的方法利用可再生生物质来合成醇生物材料.

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Production of Pharmaceuticals01:30

Production of Pharmaceuticals

Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under sterile, tightly...