在Trichophyton mentagrophytes中出现的抗真菌耐药性:从敏感性概况和遗传突变分析的见解
Yakun Shao1,2,3, Jin Shao1,2,3, Sybren de Hoog2,4
1Department of Dermatology and Venerology, Peking University First Hospital, Beijing, People's Republic of China.
Emerging microbes & infections
|January 3, 2025
概括
在Trichophyton物种中,抗真菌耐药性正在增加,导致皮肤感染. 这项研究发现Trichophyton indotineae中的terbinafine耐药性增加,并确定了与耐药性相关的基因突变,突出显示了需要新的治疗方法.
科学领域:
- 医学真菌学 医学真菌学
- 抗微生物耐药性 抗微生物耐药性
- 分子生物学分子生物学
背景情况:
- * 三植物物种是全球皮肤植物病的主要原因.
- * 增加抗真菌耐药性需要了解耐药性机制.
- * 由于缺乏对特比纳和醇的确定的耐药性标准,使管理变得复杂.
研究的目的:
- *分析Trichophyton分离物中的抗真菌易感性和耐药性基因多样性.
- * 调查来自中国的临床隔离物中的特比纳和醇耐药性模式.
- * 确定与Trichophyton物种抗真菌药物耐药性相关的遗传标记.
主要方法:
- * 最低抑制度 (MIC) 确定了特尔比纳,伊特拉可纳,沃里可纳,波萨可纳和伊萨武可纳.
- * 在Trichophyton分离物中分析了SQLE,CYP51A和CYP51B基因的遗传多样性.
- *评估了基因突变,蛋白质变化和药物敏感性之间的相关性.
主要成果:
- * 在Trichophyton indotineae分离物中观察到特尔比纳耐药性的显著增加.
- *与T. interdigitale相比,Trichophyton 蒙塔格罗菲特表现出更高的特尔比纳MIC.
- *SQLE蛋白质变异与特尔比纳芬耐药性有关,而CYP51A变化与伊特拉可纳敏感性相关.
结论:
- * 在Trichophyton物种中抗真菌耐药性的流行率不断增加是一个重大问题.
- *已识别的基因标 (SQLE,CYP51A) 为开发新型抗真菌疗法提供了潜力.
- *持续监测抗真菌耐药性和遗传多样性对于有效的皮肤植物病管理至关重要.
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