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Updated: Jul 5, 2026

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调节PD-L1的膜导向热力学与疏水纳米粒子

Xiaoqian Lin1,2,3, Xubo Lin1

  • 1Beijing Advanced Innovation Center for Biomedical Engineering, Key Laboratory of Ministry of Education for Biomechanics and Mechanobiology, School of Engineering Medicine & School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China. linxbseu@buaa.edu.cn.

Biomaterials science
|January 3, 2025
PubMed
概括

厌水纳米颗粒改变PD-L1的膜方向,增强T细胞参与癌症免疫治疗. 这种纳米医学方法提供了一种超越传统PD-L1/PD-1阻断疗法的新策略.

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Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...