非类型型沙门氏菌病与中风风险增加有关:来自多国真实世界数据的见解
Sunny Ssu-Yu Chen1,2,3, Tina Ting-An Lin1,3, Yi-Lin Chiang4
1School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
概括
非类型型沙门氏菌 (NTS) 感染显著增加了脑血管疾病 (CVD) 的风险,包括出血和缺血性中风. 这种关联在年轻人中尤为明显,突出了严重的公共卫生问题.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在全球范围内,中风是导致死亡和残疾的主要原因.
- 感染,包括非型沙门氏菌 (NTS),越来越多地被认为是导致中风的因素,特别是在低收入和中等收入国家的年轻人群中.
- 以前的研究表明,NTS和血管问题之间存在联系,因此需要进一步调查其对脑血管疾病 (CVD) 的具体影响.
研究的目的:
- 调查NTS感染与患心血管疾病的风险之间的关联.
- 为了确定在NTS感染后容易发生中风的特定患者人口统计数据.
- 分析NTS对不同类型中风的影响,包括出血性和缺血性中风.
主要方法:
- 一项使用TrinetX数据库的回顾性队列研究.
- 4708名NTS感染患者与健康的对照组进行了比较.
- 在6个月,1年和终身期间跟踪心血管疾病风险,根据年龄和性别对子组进行分析.
主要成果:
- NTS感染与心血管疾病 (HR=1.606),出血性中风 (HR=1.866) 和缺血性中风 (HR=1.717) 的终身风险显著增加有关.
- 短期和中期分析显示出出血性中风风险显著增加 (HRs>2.8).
- 男人患出血性中风的风险更高,而女性患缺血性中风的风险更大;所有年龄组的风险都显著.
结论:
- 在NTS感染和心血管疾病之间存在显著的关联.
- 在年轻人群中,NTS感染对中风,特别是出血性中风的风险很大.
- 这些发现强调了在中风预防策略中考虑NTS等传染病原体的重要性,尤其是在脆弱的人口群体中.
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