在创伤患者中增加的Citrullinated Histon H3水平和加速的Thrombin 动力学,这些患者会发展出静脉Thromboembolism
Sergio M Navarro, Riley J Thompson1, Taleen A MacArthur2
1Division of Trauma, Critical Care, and General Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota.
Shock (Augusta, Ga.)
|January 3, 2025
概括
患有静脉血栓塞栓症 (VTE) 的创伤患者表现出更高水平的素化组织素H3 (CitH3),表明中性粒细胞外细胞陷 (NET) 的形成增加. 这些患者在受伤后不久也表现出加速血栓生成 (TG) 动力学.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 创伤医学 创伤医学
背景情况:
- 中性细胞外细胞陷 (NETs) 和NETosis可能会在创伤患者中启动血栓生成 (TG).
- 静脉血栓塞栓症 (VTE) 是创伤后的一个重大并发症.
研究的目的:
- 为了调查是否创伤患者谁发展症状的VTE有高血素基素H3 (CitH3) 水平.
- 评估这些患者是否与没有VTE的患者相比表现出加速的TG动力学.
主要方法:
- 在受伤后12小时内从创伤患者和健康志愿者 (HV) 收集血样本.
- 使用ELISA和TG参数使用TG分析仪测量CitH3水平.
- 在创伤患者中,在90天内发生静脉瘤的患者和没有发生静脉瘤的患者之间的结果进行比较.
主要成果:
- 患有VTE的创伤患者的CitH3水平明显高于没有 (P=0.024).
- 这两组患者的CitH3水平比HV高 (P=0.003,P=0.012).
- 患有VTE的患者表现出加速的TG概况,包括峰值高度,内源性血栓潜力和速度指数 (所有患者P<0.05).
结论:
- 患有VTE的创伤患者表现出增加的NETosis,由升高的CitH3水平证明.
- 在这些患者中,在受伤后早期也观察到加速的TG动力学.
- 这些发现突显了NETosis,TG和VTE创伤后发展之间的潜在联系.
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