单细胞无细胞瘤与儿童血症有关,儿童怀疑感染
Lael M Yonker, Oluwakemi Badaki-Makun, Bryan Alvarez-Carcamo1
1Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts.
Shock (Augusta, Ga.)
|January 3, 2025
概括
单细胞分布宽度 (MDW) 可以帮助识别儿童的败血症. 较高的MDW水平表明严重疾病的风险更高,有助于紧急护理决策.
科学领域:
- 儿科急诊医学 儿科急诊医学
- 血液学 血液学 血液学
- 传染病诊断 传染病诊断 传染病诊断
背景情况:
- 在紧急情况下,准确的疾病严重程度评估对于患者的治疗结果和降低成本至关重要.
- 单细胞无细胞化,以单细胞分布宽度 (MDW) 来衡量,与免疫失调相关.
- 儿童血症和严重感染中MDW与疾病严重程度的关联需要进一步调查.
研究的目的:
- 调查MDW与儿童感染的疾病严重程度之间的关联.
- 评估MDW的实用性作为生物标志物用于识别儿科患者的败血症.
主要方法:
- 对2020年4月至2022年9月期间出现疾病的394名儿童的全血样本进行了回顾性分析.
- 使用UniCel DxH 900分析仪测量MDW.
- 计算SIRS标准和pSOFA分数,并记录感染源.
主要成果:
- 与没有败血症的感染儿童相比,患有败血症的儿童的MDW显著增加 (28.2 ± 7.8) (21.5 ± 5.2).
- 接收器操作特征 (ROC) 曲线分析显示,在识别败血症时,MDW的曲线下面面积为0.78.
- MDW显示出作为儿童败血症检测的有用工具的潜力.
结论:
- MDW可以作为紧急诊所医生的快速工具,以识别患重病高风险的儿童.
- 升高的MDW可以促使儿童患者更密切地监测和干预疑似败血症.
- 这种生物标志物可能有助于区分需要住院的儿童和可以安全出院的儿童.
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