肠道营养可以预防重症患者的压力吗?
Mark Borthwick1, Bethan Jenkins2, Paul E Wischmeyer3
1Departments of Pharmacy and Critical Care, Oxford University Hospitals NHS Foundation Trust, Oxford.
肠道营养 (EN) 可以降低危急病患者的胃肠道出血 (GIB) 的风险. 然而,直接证据有限,与压力预防的潜在相互作用需要进一步调查.
科学领域:
- 关键护理医学 关键护理医学
- 胃肠病学 胃肠病学
- 营养支持 营养支持
背景情况:
- 危急病患者面临由压力引起的胃肠道出血 (GIB) 高风险.
- 预防性药物用于减轻这种风险.
- 肠道营养 (EN) 是影响GIB风险的潜在因素.
研究的目的:
- 审查有关肠道营养 (EN) 对严重病患者胃肠道出血 (GIB) 的影响的现有证据.
- 评估EN和GIB风险之间的关联.
主要方法:
- 审查现有文献,包括动物模型和人类研究.
- 分析了从药理学压力预防试验中获得的数据,其中记录了EN暴露.
- 对随机营养试验的检查,注意到GIB结果记录的局限性.
主要成果:
- 对于EN对GIB的影响,存在有限的直接比较数据.
- 动物模型表明EN的有益作用.
- 人类数据提供了间接证据;一项研究将EN与较低的GIB和死亡率联系起来,但也增加了肺炎,表明与压力预防的潜在相互作用.
结论:
- 肠道营养 (EN) 可能会降低胃肠道出血 (GIB) 的风险.
- 目前缺乏强有力的直接证据.
- 需要进一步的研究来探索EN和药理学压力预防之间的相互作用.
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