类似的B型肝炎病毒在患有炎症性关节炎或结缔组织疾病的患者中重新激活风险:多中心回顾性研究
Maria Pappa1, Alexandra Koutsogianni2, Anastasios Karamanakos3
1Joint Academic Rheumatology Program, First Department of Propaedeutic and Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece. mariak.pappa@yahoo.com.
Rheumatology international
|January 3, 2025
概括
与已治愈病例相比,慢性乙型肝炎感染患者的乙型肝炎再激活率更高. 预防性抗病毒治疗没有降低自免疫性炎症性类风湿性疾病的B型肝炎患者的再激活风险.
科学领域:
- 类风湿病学 类风湿病学
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
背景情况:
- 在接受免疫抑制治疗的自身免疫性炎症性类风湿性疾病 (AIIRD) 患者中,B型肝炎的重新激活是令人担忧的.
- 除了类风湿关节炎和bDMARDs之外,许多AIIRD和药物类别的重新激活风险和预防治疗数据有限.
研究的目的:
- 在接受免疫抑制治疗的AIIRD成年患者中研究乙型肝炎病毒 (HBV) 再激活率.
- 评估HBV再激活与预防性抗病毒治疗,疾病类型 (IA与CTD) 和药物使用之间的关联.
主要方法:
- 患有AIIRD和慢性或已消失的HBV感染的成年患者被跟踪了一年.
- 收集的数据包括人口统计,AIIRD药物,HBV预防治疗和HBV重新激活事件.
- 检查了重新激活的频率和与参数的关联.
主要成果:
- 在IA的5.6%和CTD患者中的7.9%发生了HBV再激活.
- 慢性HBV (14.8%IA,22.2%CTD) 的重新激活率明显高于已解决的HBV (3.7%IA,6%CTD).
- 在已治愈的HBV病例中,预防性治疗或特定药物类别 (csDMARDs,bDMARDs) 与重新激活风险没有相关性.
结论:
- 在IA和CTD患者中,HBV重新激活的风险是相似的.
- 慢性HBV感染带来了比已治愈的感染更高的再激活风险.
- 抗病毒预防没有证明 HBV 已消失的患者的活性化风险降低.
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