与Helicobacter pylori相关的慢性胃炎作为下骨矿物质密度的危险因素
Izumi Inoue1, Noriko Yoshimura2, Toshiko Iidaka2
1Health Service Center, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-Ku, Tokyo, 108-8477, Japan. iinoue0@kaiyodai.ac.jp.
与Helicobacter pylori (H. pylori) 相关的慢性胃炎与较低的骨矿物质密度和骨质疏松症风险增加有关. 胃炎的严重程度和缩的进展显著提高了这种风险,有助于识别高风险个体.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 类风湿病学 类风湿病学
背景情况:
- 杆菌 (H. pylori) 感染是慢性胃炎的常见原因之一.
- 骨质疏松症是一个重要的公共卫生问题,其特点是骨矿物质密度 (BMD) 低.
- 与H. pylori相关的胃炎和骨质疏松症风险之间的潜在联系需要进一步调查.
研究的目的:
- 评估与H. pylori相关的慢性胃炎和骨质疏松症的发展之间的关联.
- 评估胃炎的阶段和活动如何影响骨质疏松症风险.
- 确定胃炎的血清学评估是否可以识别患骨质疏松症高风险的个体.
主要方法:
- 一项以人口为基础的研究,涉及1690名来自骨关节炎/骨质疏松症与残疾 (ROAD) 研究队伍的受试者.
- 对H. pylori感染的血清学评估,包括抗体标位和pepsinogen水平,以确定胃炎的存在和阶段.
- 使用双能X射线吸收计 (DXA) 测量骨矿物质密度 (BMD).
主要成果:
- 与H. pylori相关的慢性胃炎与显著降低的BMD有关.
- 在大腿部观察到较低BMD的显著风险 (调整后OR:0.78).
- 胃炎活动的增加和更广泛的缩阶段 (非缩和缩) 与逐渐更高的下部BMD风险有关.
结论:
- 与H. pylori相关的慢性胃炎是导致骨质疏松症风险的一个因素.
- 胃炎的严重程度,包括活性和缩,与骨质疏松症风险增加直接相关.
- 胃炎的血清分期可以帮助识别患有骨质疏松症高风险的H. pylori感染个体.
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