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Updated: May 7, 2025

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

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复杂的遗传相互作用会影响BIN1和MS4A6A位点对阿尔茨海默病风险的敏感性

Alireza Nazarian1, Marissa Morado2, Alexander M Kulminski3

  • 1Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Erwin Mill Building, 2024 W. Main St, Durham, NC, 27705, USA. alireza.nazarian@duke.edu.

GeroScience
|January 3, 2025
PubMed
概括

遗传因素显著影响阿尔茨海默病 (AD) 风险. 这项研究表明,单核酸多态性 (SNPs) 在BIN1和MS4A6A位点中的综合作用,而不仅仅是单个SNP,对于AD易感性至关重要.

关键词:
衰老的衰老 衰老的衰老阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.复合基因型是一种复合基因型.痴呆症是一种痴呆症.遗传关联 遗传关联遗传的异质性 遗传的异质性遗传相互作用 遗传相互作用

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