相关实验视频

Updated: Jun 4, 2025

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

高CD38表达定义了适应线粒体功能的CD8+T细胞子集,对肺癌免疫治疗有影响

Lei-Lei Lv¹, Jia-Wei Zhai^1,2, Jia-Juan Wu³

¹Department of Respiratory and Critical Medicine, the First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou, 215006, China.

Cancer immunology, immunotherapy : CII

|January 3, 2025

概括

CD38^hiCD8⁺ 肺癌中的T细胞通过线粒体功能障碍与免疫疗法抵抗有关. 通过EGCG和PD-1阻断向CD38,可以恢复T细胞功能并改善治疗反应.

科学领域:

免疫学免疫学免疫学
癌症生物学癌症生物学
分子医学是分子医学.

背景情况:

特定的CD8+T细胞子集有助于免疫疗法耐药性,但潜在的分子机制尚不清楚.
CD38在CD8⁺ T细胞功能中的作用表明它参与调节肺癌中T细胞反应.

研究的目的:

为了研究CD38⁺CD8⁺ T细胞在肺癌中的积累和功能.
探索CD38⁺CD8⁺ T细胞在抵抗免疫检查点阻塞 (ICB) 治疗中的作用.
评估针对CD38的治疗策略,以克服ICB耐药性.

主要方法:

来自肺癌患者和临床前模型的瘤CD8⁺ T细胞的表型分析.
评估疲劳标记,线粒体生物能学和细胞因子生产 (IFN-γ).
在ICB耐药小鼠肺癌模型中对组合疗法 (PD-L1 mAbs和EGCG) 的评估.

主要成果:

CD38⁺CD8⁺ T细胞包括CD38^hi和CD38^int子集,其疲劳标记和线粒体功能受损.
瘤微环境中CD38^hi和CD8⁺ T细胞的增加与非小细胞肺癌中抗PD-1治疗的良好反应相关.
用PD-L1 mAbs和EGCG进行组合治疗可选择性地减少CD38^hiCD8⁺T细胞,增强IFN-γ,并改善耐药模型的生存率.

结论:

与CD38相关的线粒体功能障碍驱动CD8⁺ T细胞耗尽和对ICB治疗的内在抵抗.
向CD38提供了一个潜在的策略,以提高PD-1阻断在肺癌中的有效性.
恢复CD38^hiCD8⁺T细胞中的线粒体功能对于恢复免疫治疗敏感性至关重要.

关键词:

CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD8+ T 细胞细胞免疫检查站封锁免疫检查站封锁肺癌是一种肺癌.线粒体中的线粒体.在PD-1中使用PD-1.

更多相关视频

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

相关概念视频

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...