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转移素受体从与瘤相关的中性粒细胞中吸收铁,以调节OSCC的入侵模式

Qian Si^1,2, Yuhan Wang^1,3, Wanqiu Lu⁴

¹Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, China.

Cancer immunology, immunotherapy : CII

|January 3, 2025

概括

转移素受体 (TFRC) 通过增强细胞迁移和增殖,特别是瘤前端,促进口腔癌的入侵. 这一轴涉及与瘤相关的中性粒细胞和转激素,影响患者的治疗结果.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

转移素受体 (TFRC) 促进铁的吸收,并影响瘤的发展.
转激素 (TF) -TFRC轴在口腔状细胞癌 (OSCC) 中的作用及其异质表达仍然不清楚.
了解TF-TFRC轴对于OSCC进展和治疗策略至关重要.

研究的目的:

研究TF-TFRC轴在OSCC中的临床意义和功能作用.
探索区域TFRC表达异质性对OSCC发展的影响.
在OSCC中阐明TFRC,瘤相关中性粒细胞 (TAN) 和TF之间的关系.

主要方法:

免疫组织化学 (IHC) 用于评估106名OSCC患者的TFRC表达.
对具有不同TFRC水平的OSCC细胞进行功能性检测,以评估迁移和增殖.
多免疫光分析TF和TANs的共同表达.
使用TCGA数据进行体外和跨患者子组TF效应的比较.

主要成果:

在侵入性瘤前线 (ITF) 观察到更高的TFRC表达,与最糟糕的入侵模式 (WPOI) 相相关.
在WPOI 4-5患者中,TFRC作为ITF的预后因素,促进癌细胞迁移和扩散.
TANs分泌了TF,外源TF增强了高TFRC细胞的迁移和繁殖,TANs高/TFRC高的患者表现较差.

结论:

在ITF和TANs-TF-TFRC轴上的TFRC升高通过促进细胞迁移和增殖,有助于OSCC入侵.
细胞铁吸收增加,由铁代谢调节,似乎是关键机制.
针对TF-TFRC轴可以为OSCC提供新的治疗策略.

关键词:

口腔状细胞癌的癌症.预测预后预测预测转移氨酸受体的受体转移氨酸受体与瘤相关的中性粒细胞最糟糕的入侵模式

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