在产前暴露于系统性葡萄皮质激素的后代中出现精神障碍
Kristina Laugesen1,2, Nils Skajaa1, Irene Petersen1,3
1Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
JAMA network open
|January 3, 2025
概括
产前暴露于葡萄糖皮质类药物与后代患某些心理健康状况的风险增加有关. 这项研究强调了在怀孕期间处方这些药物时需要谨慎.
科学领域:
- 围产阶段精神病学 围产阶段精神病学
- 发展心理学 发展心理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 有限证据表明,产前暴露于葡萄糖皮质激素对心理健康的长期影响有限.
- 了解这些关联对于母婴健康至关重要.
- 在怀孕期间使用葡萄糖皮质激素是各种孕产妇疾病的常见病例.
研究的目的:
- 调查产前暴露于全身糖皮质激素和15岁以下后代的精神障碍之间的关联.
- 为了比较暴露和未暴露的后代的结果,这些后代来自具有相似潜在疾病的母亲.
主要方法:
- 全国基于人口的队列研究,使用丹麦登记数据 (1996-2016).
- 包括超过100万名婴儿,分析那些接触过葡萄糖皮质醇的人与未接触过的婴儿.
- 对自闭症谱系障碍,智力障碍,多动症和情绪/焦虑障碍的风险进行比较.
主要成果:
- 产前皮质激素暴露与患自闭症谱系障碍 (RR 1.5),多动症 (ADHD) (RR 1.3),情绪/焦虑障碍 (RR 1.5) 的风险增加有关,这些风险在患早产风险的母亲的后代中增加.
- 在患有自身免疫/炎症性疾病的母亲的后代中观察到类似的增加风险,包括自闭症谱系障碍 (RR 1.3),ADHD (RR 1.3),以及情绪/焦虑障碍 (RR 1.4).
- 不能完全排除疾病严重程度的混.
结论:
- 产前葡萄糖皮质激素暴露与后代患特定精神障碍的风险更高有关.
- 这些发现支持在怀孕期间谨慎使用糖皮质激素.
- 需要进一步的研究来阐明机制并确认发现.
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