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Updated: Jun 4, 2025

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在薄膜中"稳定"无形二烯

Chaima Tizaoui^1,2,3, Ivo B Rietveld¹, Haykel Galai^2,3

¹Univ. Rouen Normandie, Normandie Univ., SMS, UR 3233, F-76000 Rouen, France.

Langmuir : the ACS journal of surfaces and colloids

|January 3, 2025

概括

无形烯薄膜在干燥条件下表现出稳定性,但在潮湿环境中结晶. 聚乙烯甘醇添加影响结晶,低度和高湿度导致纳米尺寸的晶体.

科学领域:

材料科学材料科学材料科学
制药科学制药科学
物理化学物理化学

背景情况:

无形固体分散对于提高药物的溶解性和生物可用性至关重要.
托芬是一种非类固醇抗炎药物,通常需要在其无形形式的稳定.
薄膜沉积提供了一种控制药物配方和稳定性的方法.

研究的目的:

为了研究无形烯在薄膜中的稳定性.
为了评估聚乙烯糖醇 (PEG) 和相对湿度对的无形状态的影响.
了解基托在无形薄膜中的结晶行为.

主要方法:

使用螺旋涂层制备无形基/PEG薄膜.
在不同的相对湿度条件下,薄膜稳定性的表征.
使用光谱X射线衍射和原子力显微镜进行分析.

主要成果:

在干燥条件下,无形烯薄膜在长达4个月的时间内保持稳定.
在暴露于相对湿度>50%的薄膜中观察到烯的结晶.
低度的二烯和高湿度导致纳米尺寸的晶体,而PEG的效果取决于度.

结论:

薄膜沉积稳定无形基,防止在干燥条件下结晶.
湿度是诱导无形烯膜结晶的关键因素.
聚乙烯甘醇的存在和度可以调节 ketoprofen 在无形膜中的结晶动力学.

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