氧化平衡指标与慢性病之间的关系
Xinyun Chen1, Fangyu Shi1, Wenhui Yu2
1Department of Health Management, Health Management Center, General Practice Center, West China Hospital, Sichuan University, Chengdu, China.
PloS one
|January 3, 2025
概括
氧化平衡评分 (OBS) 和亲氧化剂-抗氧化剂平衡 (PAB) 的较高水平与慢性病 (CKD) 的风险较低有关. OBS显示了对CKD风险最强的预测能力.
科学领域:
- 生物化学和氧化应激 氧化应激
- 科和脏疾病研究研究
- 公共卫生和流行病学
背景情况:
- 慢性病 (CKD) 影响全球大约9.1%的人口,代表着严重的公共卫生问题.
- 氧化应激与CKD的发病有关,像氧化平衡得分 (OBS),亲氧化剂-抗氧化剂平衡 (PAB) 和总抗氧化能力 (TAC) 这样的指标具有研究兴趣.
- 这些氧化平衡标志物与CKD风险之间的确切关联仍然不完全理解.
研究的目的:
- 研究关键氧化平衡指标 (OBS,PAB,TAC) 与患慢性病 (CKD) 的风险之间的关联.
- 评估OBS,PAB和TAC在评估CKD风险中的预测性能.
- 探索氧化平衡在CKD预防策略中的潜在作用.
主要方法:
- 从2009-2018年国家健康和营养检查调查 (NHANES) 中对18951名参与者的横截面分析.
- 使用后勤回归和受限立方线回归模型来检查氧化平衡指标和CKD之间的关联.
- 进行了接收器操作特征 (ROC) 曲线分析,以评估OBS,PAB和TAC对CKD风险的预测准确性.
主要成果:
- 高水平的OBS和PAB与慢性脏病风险降低显著相关,即使经过调整以考虑混因素 (OR = 0.97,P < 0.001对于OBS;OR = 0.94,P < 0.001对于PAB).
- 在OBS和PAB的最高四分位数中,与CKD风险有实质性的反向关联 (OR=0.60,P<0.001对于OBS;OR=0.77,P=0.013对于PAB).
- 总抗氧化能力 (TAC) 没有证明与CKD有显著的关联. OBS表现出对CKD风险最强的预测能力 (AUC = 0.579).
结论:
- 氧化平衡指标,特别是OBS和PAB,与CKD风险相反相关,表明具有保护作用.
- 在本研究群体中,TAC没有显示出与CKD的显著关联.
- 在评估的指标中,OBS成为CKD风险的最强有力的预测指标,这强调了氧化平衡对脏健康和潜在预防策略的重要性.
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