在公共大学环境中,SARS-CoV-2的Omicron变种导致了广泛增加的血清流行率
Ching-Wen Hou1, Stacy Williams1, Guillermo Trivino-Soto1
1Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America.
PLOS global public health
|January 3, 2025
概括
欧米克朗变种显著增加了SARS-CoV-2抗体血清流行率,而抗核囊抗体几乎翻了一番. 唾液检测也显示出对监测感染趋势的前景.
科学领域:
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
- 病毒学 病毒学
背景情况:
- 奥米克朗是最易传播的严重急性呼吸系统综合征-冠状病毒-2 (SARS-CoV-2) 变种.
- 了解抗体血清流行对于评估人口免疫力和感染趋势至关重要.
研究的目的:
- 在Omicron爆发后的成年人中调查SARS-CoV-2抗体血清流行.
- 为了将当前的血清流行率与以前的发现进行比较.
- 评估唾液作为用于抗体检测的诊断生物流体.
主要方法:
- 在18岁及以上的个人中,从2022年3月1日至3月3日进行了血清流行研究.
- 在血清样本中测量了抗受体结合域 (RBD) 和抗核体 (NC) 抗体.
- 将唾液抗体水平与血清抗体水平进行比较.
主要成果:
- 抗RBD抗体血清流行率从88.2%上升到96.3%,从88.2%上升到96.3%.
- 反NC抗体血清流行率从19.7%增加到39.1%,表明感染率更高.
- 突破性感染的个体具有最高的抗RBD抗体水平.
- 唾液样本与用于抗体测量的血清样本有很强的一致性.
结论:
- 欧米克朗变种导致SARS-CoV-2抗体血清流行率大幅增加.
- 反NC抗体的增加反映了Omicron的传染性和可能放宽的公共卫生措施.
- 唾液是用于血清检测的可行的替代生物流体.
- 定期的血清检查对于跟踪感染和指导公共卫生反应至关重要.
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