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相关概念视频

Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

714
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
714
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

522
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
522
T Cell Types and Functions01:24

T Cell Types and Functions

613
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
613
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

593
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
593
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

1.1K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.1K
Tumor Immunotherapy01:27

Tumor Immunotherapy

394
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
394

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相关实验视频

Updated: May 7, 2025

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
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High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

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斯尼普尔警报!这是一个危险的信号. 使T细胞成为更精确的杀手.

Jonathan Chuck1,2, Laura A Solt1,2

  • 1Department of Immunology and Microbiology, Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458, USA.

Science immunology
|January 3, 2025
PubMed
概括

现在可以精确控制细胞信号通路. 这种细胞工程策略利用自然和人工分子进行有针对性的调节.

科学领域:

  • 细胞生物学 细胞生物学
  • 分子工程是分子工程.

背景情况:

  • 细胞信号通路对于细胞功能至关重要.
  • 细胞信号的失调有助于各种疾病.
  • 现有的控制细胞信号的方法有局限性.

研究的目的:

  • 开发一种用于精确调节细胞信号的新型细胞工程方法.
  • 调查使用内源性和合成联结物的疗效.

主要方法:

  • 采用先进的细胞工程技术.
  • 设计和合成新的配体.
  • 利用自然存在的和人工合成的连接体来调节特定的信号通路.

主要成果:

  • 对关键细胞信号通路的精确控制.
  • 验证了内源和合成配体在调节信号传输中的有效性.
  • 展示了针对性治疗干预的潜力.

结论:

  • 细胞工程为微调细胞通信提供了一个强大的平台.
  • 结合使用内源和合成连接体,为信号调制提供了多功能工具包.

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Killer Artificial Antigen Presenting Cells KaAPC for Efficient In Vitro Depletion of Human Antigen-specific T Cells
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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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相关实验视频

Last Updated: May 7, 2025

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
11:31

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

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Killer Artificial Antigen Presenting Cells KaAPC for Efficient In Vitro Depletion of Human Antigen-specific T Cells
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Killer Artificial Antigen Presenting Cells KaAPC for Efficient In Vitro Depletion of Human Antigen-specific T Cells

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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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  • 这种方法对推进基于细胞的疗法和了解细胞机制充满希望.