肉酸降低血压,并逆转大鼠的血管内皮功能障碍
Abdul Jabbar Shah1, Hafiz Misbah-Ud-Din Qamar2, Umme Salma2,3
1Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.
Journal of food and drug analysis
|January 3, 2025
概括
酸 (CA) 在老鼠中显示出显著的抗高血压作用,通过血管扩张降低血压,并降低心率. 这些发现突出了CA的CA.
科学领域:
- 心血管药理学心血管药理学
- 自然产品化学 自然产品化学
背景情况:
- 酸 (CA) 具有心脏保护性,抗动脉发性,抗高脂性和抗氧化性质.
- 这些特征表明CA在管理高血压方面具有潜在的治疗作用.
研究的目的:
- 在Sprague Dawley大鼠中研究酸 (CA) 的抗高血压潜力.
- 阐明CA血管和心脏影响的潜在机制.
主要方法:
- 在正常血压和高血压麻醉大鼠中进行侵入性血压监测.
- 评估隔离的老鼠大动脉环,子大动脉环,Langendorff透的子心脏和几内亚猪的右心房.
- 使用连接到PowerLab数据采集系统的压力和力传感器测量血管反应和心脏收缩率.
主要成果:
- 静脉注射CA使高血压大鼠的平均动脉压 (MAP) 降低了54%,高血压大鼠的平均动脉压降低了38%.
- 通过与肌肉蛋白受体结合的氧化 (NO) 和由对抗和KATP通道介导的内皮独立血管扩张,CA诱导了依赖内皮的血管扩张 (> 50%).
- CA对几内亚猪心房条呈现负面的内和慢作用,抑制了心室收缩力和心率,并增加了冠状动脉流量25%.
结论:
- 锡南酸具有显著的抗高血压特性.
- CA通过多种机制发挥其作用,包括血管扩张和负心脏内热/时热作用.
- 这些发现支持CA作为潜在的抗高血压剂的药用重要性.
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