Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

3.9K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Dietary tryptophan regulates carcass traits, meat quality, flavor and antioxidant capacity of finishing pigs.

Food chemistry·2026
Same author

Effects of dietary berberine hydrochloride on growth, immunity, meat quality, and fecal microbiota in broiler chickens.

Frontiers in veterinary science·2026
Same author

Effects of Neutral Electrolytic Water on Growth, Carcass, and Gut Microbiota of Arbor Acres Plus (AA+) Broilers.

Animal science journal = Nihon chikusan Gakkaiho·2026
Same author

Effects of dietary valine/isoleucine ratio and slaughter weight on the composition of pork flavor precursors.

Animal nutrition (Zhongguo xu mu shou yi xue hui)·2025
Same author

Engineered Osteochondral Scaffolds with Bioactive Cartilage Zone for Enhanced Articular Cartilage Regeneration.

Annals of biomedical engineering·2024
Same author

Inflammation-targeted delivery of Urolithin A mitigates chemical- and immune checkpoint inhibitor-induced colitis.

Journal of nanobiotechnology·2024

相关实验视频

Updated: May 5, 2026

Human Cartilage Tissue Fabrication Using Three-dimensional Inkjet Printing Technology
09:32

Human Cartilage Tissue Fabrication Using Three-dimensional Inkjet Printing Technology

Published on: June 10, 2014

15.7K

脱细胞化软骨组织生物油墨配方,用于骨质冠状腺移植的发育.

Aleksandra A Golebiowska1, Mingyang Tan2, Anson Wk Ma2,3

  • 1Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, United States of America.

Biomedical materials (Bristol, England)
|January 3, 2025
PubMed
概括

研究人员开发了一本小说.

关键词:
关节软骨 - 关节软骨生物活性生物材料/墨水脱细胞化的软骨软骨.组织生物墨水组织工程是组织工程.粘度调整剂 粘度调整剂

更多相关视频

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
08:02

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Published on: January 7, 2019

11.0K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

936

相关实验视频

Last Updated: May 5, 2026

Human Cartilage Tissue Fabrication Using Three-dimensional Inkjet Printing Technology
09:32

Human Cartilage Tissue Fabrication Using Three-dimensional Inkjet Printing Technology

Published on: June 10, 2014

15.7K
Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
08:02

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Published on: January 7, 2019

11.0K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

936

科学领域:

  • 组织工程是组织工程.
  • 生物材料科学 生物材料科学
  • 再生医学是一种再生医学.

背景情况:

  • 关节软骨和骨髓缺陷对组织工程 (TE) 和再生医学构成重大挑战.
  • 目前的工程支架努力复制本地微环境以实现最佳再生.
  • 开发模仿本地软骨的生物材料对于有效的修复至关重要.

研究的目的:

  • 从脱细胞化软骨外细胞基质 (dcECM) 开发可打印的生物材料,用于软骨组织再生.
  • 为了研究粘度调整剂 (香丹,拉波尼特®) 和照片交叉连接对生物油墨特性的影响.
  • 为了创建一个稳定的,可注射的"软骨墨水",支持chondrogenesis.

主要方法:

  • 关节软骨的脱细胞化和溶解,形成dcECM.
  • 配制dcECM生物墨水,使用香 (XG) 或拉波尼特 (Laponite®) 和一个可相交链接的组件.
  • 病理学性质 (粘度,剪切薄化,存储/损失模块) 以评估可印和稳定性.
  • 在体外评估细胞活力和使用人类骨髓衍生的树皮细胞和树皮细胞的chondrogenic分化.

主要成果:

  • dcECM-Laponite®生物墨水的储存模量 (7504000Pa) 比 dcECM-XG配方的储存模量要高得多.
  • 生物油墨配方展示了可调整的三维打印和形状保真后紫外线交叉连接的3D打印.
  • 拉波尼特®的添加改善了生物墨水的稳定性,并使生长因子的持续释放成为可能.
  • 基于ECM的生物墨水支持细胞活力,并增强了体内体差异化.

结论:

  • 从脱细胞化的软骨ECM成功开发出可打印和稳定的"软骨油墨".
  • 生物墨水密切模仿本地软骨ECM结构和功能,支持软骨组织的形成.
  • 这种生物材料有望在关节软骨修复中推进TE策略.